Bioinformatics Analysis of Effects of Rosmarinus officinalis L., Zataria multiflora Boiss L. and Mentha piperita L. Compounds on Pseudomonas aeruginosa Biofilm Formation Using Molecular Docking

Hatami Pirghibi, Tayebeh; Chehri, Khosrow; Karimi, Issac; Abiri, Ramin

doi:10.22084/ab.2023.22909.1445

Bioinformatics Analysis of Effects of Rosmarinus officinalis L., Zataria multiflora Boiss L. and Mentha piperita L. Compounds on Pseudomonas aeruginosa Biofilm Formation Using Molecular Docking

Document Type : Research Paper

Authors

Tayebeh Hatami Pirghibi ¹

Khosrow Chehri ²

Issac Karimi ³

Ramin Abiri ⁴

¹ MSc Student, Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran

² Associate Professor, Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran.

³ Associate Professor, Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran

⁴ Associate Professor, Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

10.22084/ab.2023.22909.1445

Abstract

Today, according to the widespread of antibiotic resistance, plants have attracted considerable interest to combat bacterial infections. One of the most important limitations of different studies on antibacterial effects of plant extracts is that the exact phytochemical compounds responsible for antibacterial effect are unknown. The aim of current study was to pursue bioinformatics analysis of effects of phytochemical compounds of Rosmarinus officinalis L., Zataria multiflora Boiss L. and Mentha piperita L. (genera of Lamiaceae family) on Pseudomonas aeruginosa biofilm formation to determine the exact compound(s) responsible for inhibition of bacterial biofilm formation. PyRx software 0.8 was used to perform docking process. Results of this study showed that phytochemical compounds of selected plants bind to the essential protein of LasR and inhibit it. Based on results of molecular docking, Borneol, Linalool, and Dihydrocarvone compounds reported for Rosmarinus officinalis L., Zataria multiflora Boiss L., Mentha piperita L., respectively showed high affinity to LasR protein and they can be considered as anti-Pseudomonal candidates.

Keywords

Phytochemical compounds

LasR

Quorum sensing

Lamiaceae

Subjects